The following PhD-theses and peer-reviewed papers directly related to NeuroPharm have been published in 2016-21.

2021

Papers:

  1. Brandt IM, Köhler-Forsberg K, Ganz M, Ozenne B, Jorgensen MB, Poulsen A, Knudsen GM, Frokjaer VG, Fisher PM. Reward processing in major depressive disorder and prediction of treatment response - Neuropharm study. Eur Neuropsychopharmacol. 2021 Mar;44:23-33
  2. Dam V, Stenbæk DS, Köhler-Forsberg K, Ip C, Ozenne B, Sahakian BJ, Knudsen GM, Jørgensen MB, Frokjaer VG. Hot and cold cognitive disturbances in antidepressant-free patients with Major Depressive Disorder: A NeuroPharm study. Psychol Med. 2020 Apr 22;1-10 [Epub ahead of print]
  3. Donovan LL, Johansen JV, Ros NF, Jaberi E, Linnet K, Johansen SS, Ozenne B, Issazadeh-Navikas S, Hansen HD, Knudsen GM. Effects of a single dose of psilocybin on behaviour, brain 5-HT2A receptor occupancy and gene expression in the pig. Eur Neuropsychopharmacol. 2021 Jan;42:1-11
  4. Ip CT, Olbrich S, Ganz M, Ozenne B, Köhler-Forsberg K, Dam VH, Beniczky S, Jørgensen MB, Frokjaer VG, Søgaard B, Christensen SR, Knudsen GM. Pretreatment qEEG biomarkers for predicting pharmacological treatment outcome in major depressive disorder: Independent validation from the NeuroPharm study. Eur Neuropsychopharmacol. 2021 Apr 25;49:101-112 [Epub ahead of print]
  5. Jørgensen LM, Henriksen T, Mardosiene S, Keller SH, Stenbæk DS, Hansen HD, Jespersen B, Thomsen C, Weikop P, Svarer C, Knudsen GM. Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study. J Cereb Blood Flow Metab. 2021 Jan 18:271678X20982389. doi: 10.1177/0271678X20982389. [Epub ahead of print]
  6. Madsen MK, Knudsen GM. Plasma psilocin critically determines behavioral and neurobiological effects of psilocybin. Neuropsychopharmacology. 2021 Jan;46(1):257-258
  7. Marstrand-Joergensen MR, Madsen MK, Stenbæk DS, Ozenne B, Jensen PS, Frokjaer VG, Knudsen GM, Fisher PM. Default Mode Network Functional Connectivity Negatively Associated with Trait Openness to Experience. Soc Cogn Affect Neurosci. 2021 Apr 23:nsab048. [Epub ahead of print]
  8. Ozenne B, Fisher PM, Budtz-Jørgensen E. Small sample corrections for Wald tests in Latent Variable Models. Journal of the Royal Statistical Society (Accepted)
  9. Stenbæk DS, Madsen MK, Ozenne B, Kristiansen S, Burmester D, Erritzoe D, Knudsen GM, Fisher PM. Brain serotonin 2A receptor binding predicts subjective temporal and mystical effects of psilocybin in healthy humans. J Psychopharmacol. 2021 Apr;35(4):459-468
  10. Zarp Petersen J, Varo C, Skovsen CF, Ott CV, Kjaerstad HL, Vieta E, Harmer CJ, Knudsen GM, Kessing LV, Macoveanu J, Miskowiak KW. Neuronal underpinnings of cognitive impairment in bipolar disorder: A large data-driven functional magnetic resonance imaging study. Bipolar Disord. 2021 May 6. doi: 10.1111/bdi.13100. [Epub ahead of print]

 

2020

PhD-theses:

  1. Köhler-Forsberg K. The serotonin 4 receptor binding as a novel imaging marker in major depressive disorder and the association to antidepressant treatment response. København: Eget forlag 2020:1-60. Forsvaret d. 26.06.2020 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet

Papers:

  1. Donovan LL, Magnussen JH, Dyssegaard A, Lehel S, Hooker JM, Knudsen GM, Hansen HD. Imaging HDACs In Vivo: Cross-Validation of the [11C]Martinostat Radioligand in the Pig Brain. Mol Imaging Biol. 2020 Jun;22(3):569-577
  2. Erritzoe D, Ashok AH, Searle GE, Colasanti A, Turton S, Lewis Y, Huiban M, Moz S, Passchier J, Saleem A, Beaver J, Lingford-Hughes A, Nutt DJ, Howes OD, Gunn RN, Knudsen GM, Rabiner EA. Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge. Neuropsychopharmacology. 2020 Apr;45(5):804-810
  3. Hansen HD, Lindberg U, Ozenne B, Fisher PM, Johansen A, Svarer C, Keller SH, Hansen AE, Knudsen GM. Visual stimuli induce serotonin release in occipital cortex: A simultaneous positron emission tomography/magnetic resonance imaging study. Hum Brain Mapp. 2020 Aug 19;41(16):4753-4763
  4. Holst KK, Budtz-Jørgensen E. A two-stage estimation procedure for non-linear structural equation models. Biostatistics. 2020 Oct 1;21(4):676-691
  5. Köhler-Forsberg K, Jorgensen A, Dam VH, Stenbæk DS, Fisher PM, Ip CT, Ganz M, Poulsen HE, Giraldi A, Ozenne B, Jørgensen MB, Knudsen GM, Frokjaer VG. Predicting Treatment Outcome in Major Depressive Disorder Using Serotonin 4 Receptor PET Brain Imaging, Functional MRI, Cognitive-, EEG-Based, and Peripheral Biomarkers: A NeuroPharm Open Label Clinical Trial Protocol. Front Psychiatry. 2020 Jul 23;11:641
  6. Madsen MK, Fisher PM, Stenbæk DS, Kristiansen S, Burmester D, Lehel S, Páleníček T, Kuchař M, Svarer C, Ozenne B, Knudsen GM. A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding. Eur Neuropsychopharmacol. 2020 Apr;33:71-80
  7. Ozenne BMH, Scheike TH, Staerk L, Gerds TA. On the estimation of average treatment effects with right-censored time to event outcome and competing risks. Biom J. 2020 May;62(3):751-763
  8. Sander CY, Hansen HD, Wey HY. Advances in simultaneous PET/MR for imaging neuroreceptor function. J Cereb Blood Flow Metab. 2020 Jun;40(6):1148-1166

 

2019

PhD-theses:

  1. Deen M. PET investigations of brain serotonin receptor binding in migraine patients. København: Eget forlag 2018:1-54. Forsvaret d. 04.01.2019 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet

Papers:

  1. Deen M, Hougaard A, Hansen HD, Svarer C, Eiberg H, Lehel S, Knudsen GM, Ashina M. Migraine is associated with high brain 5-HT levels as indexed by 5-HT4 receptor binding. Cephalalgia. 2019 Apr;39(4):526-532
  2. Deen M, Hougaard A, Hansen HD, Schain M, Dyssegaard A, Knudsen GM, Ashina M. Association Between Sumatriptan Treatment During a Migraine Attack and Central 5-HT1B Receptor Binding. JAMA Neurol. 2019 Jul 1;76(7):834-840
  3. Madsen MK, Fisher PM, Burmester D, Dyssegaard A, Stenbæk DS, Kristiansen S, Johansen SS, Lehel S, Linnet K, Svarer C, Erritzoe D, Ozenne B, Knudsen GM. Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels. Neuropsychopharmacology. 2019 Jun;44(7):1328-1334
  4. Ott CV, Vinberg M, Bowie CR, Christensen EM, Knudsen GM, Kessing LV, Miskowiak KW. Correction to: Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial. Trials. 2019 Apr 8;20(1):20

Book chapters:

  1. Landolt HP, Holst SC, Valomon A. Clinical and Experimental Human Sleep-Wake Pharmacogenetics. Handb Exp Pharmacol. 2019;253:207-241. doi: 10.1007/164_2018_175.

 

2018

PhD-theses:

  1. Beliveau V. Functional and Molecular Imaging of the Serotonin System in the Human Brain. København: Eget forlag 2018:1-54. Forsvaret d. 27.02.2018 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet
  2. Jørgensen LM. Pharmacological and DBS-induced changes in cerebral serotonin release. København: Eget forlag 2018:1-82. Forsvaret d. 09.03.2018 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Papers:

  1. Deen M, Hansen HD, Hougaard A, Nørgaard M, Eiberg H, Lehel S, Ashina M, Knudsen GM. High brain serotonin levels in migraine between attacks: A 5-HT4 receptor binding PET study. Neuroimage Clin. 2018 Jan 28;18:97-102
  2. Deen M, Hansen HD, Hougaard A, da Cunha-Bang S, Nørgaard M, Svarer C, Keller SH, Thomsen C, Ashina M, Knudsen GM. Low 5-HT1B receptor binding in the migraine brain: A PET study. Cephalalgia. 2018 Mar;38(3):519-527
  3. Ott CV, Vinberg M, Bowie CR, Christensen EM, Knudsen GM, Kessing LV, Miskowiak KW. Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial. Trials. 2018 Sep 12;19(1):487

 

2017

  1. Deen M, Christensen CE, Hougaard A, Hansen HD, Knudsen GM, Ashina M. Serotonergic mechanisms in the migraine brain - a systematic review. Cephalalgia. 2017 Mar;37(3):251-264
  2. Hansen HD, Mandeville JB, Sander CY, Hooker JM, Catana C, Rosen BR, Knudsen GM. Functional characterization of 5-HT1B receptor drugs in nonhuman primates using simultaneous PET-MR. J Neurosci. 2017 Nov 1;37(44):10671-10678
  3. Stenbæk DS, Dam VH, Fisher PM, Hansen N, Hjordt LV, Frøkjær VG. No evidence for a role of the serotonin 4 receptor in five-factor personality traits: A positron emission tomography brain study. PLoS One. 2017 Sep 7;12(9):e0184403

 

2016

  1. Mandeville JB, Sander CY, Wey HY, Hooker JM, Hansen HD, Svarer C, Knudsen GM, Rosen BR. A regularized full reference tissue model for PET neuroreceptor mapping. Neuroimage. 2016 Jun 27;139:405-414