The following PhD-theses and peer-reviewed papers directly related to NeuroPharm have been published in 2016-23.

2023

Papers:

  1. Ip CT, Ganz M, Ozenne B, Olbrich S, Beliveau V, Dam VH, Köhler-Forsberg K, Jørgensen MB, Frøkjær VG, Knudsen GM. Association between the loudness dependence of auditory evoked potential, serotonergic neurotransmission and treatment outcome in patients with depression. Eur Neuropsychopharmacol. 2023 May;70:32-44
  2. Köhler-Forsberg K, Dam VH, Ozenne B, Sankar A, Beliveau V, Landman EB, Larsen SV, Poulsen AS, Ip CT, Jørgensen A, Meyer M, Stenbæk DS, Eiberg HRL, Madsen J, Svarer C, Jørgensen MB, Frokjaer VG, Knudsen GM. Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction. JAMA Psychiatry. 2023 Apr 1;80(4):296-304
  3. Macoveanu J, Mariegaard J, Petersen JZ, Fisher PM, Vinberg M, Jørgensen MB, Knudsen GM, Kessing LV, Miskowiak KW. Neural basis of memory impairments and relation to functional disability in fully or partially remitted patients with affective disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Jul 13;125:110767
  4. Rasmussen AL, Larsen SV, Ozenne B, Köhler-Forsberg K, Stenbæk DS, Jørgensen MB, Giraldi A, Frokjaer VG. Sexual health and serotonin 4 receptor brain binding in unmedicated patients with depression-a NeuroPharm study. Transl Psychiatry. 2023 Jul 6;13(1):247
  5. Rüesch A, Villar de Araujo T, Bankwitz A, Hörmann C, Adank A, Ip CT, Schoretsanitis G, Kleim B, Olbrich S. A recent suicide attempt and the heartbeat: Electrophysiological findings from a trans-diagnostic cohort of patients and healthy controls. J Psychiatr Res. 2023 Jan;157:257-263
  6. Vulpius GM, Köhler-Forsberg K, Ozenne B, Larsen SV, Nasser A, Svarer C, Gillings N, Keller SH, Jørgensen MB, Knudsen GM, Frokjaer VG. Stress Hormone Dynamics Are Coupled to Brain Serotonin 4 Receptor Availability in Unmedicated Patients With Major Depressive Disorder: A NeuroPharm Study. Int J Neuropsychopharmacol. 2023 Sep 25;26(9):639-648

 

2022

Papers:

  1. Beliveau V, Hedeboe E, Fisher PM, Dam VH, Jørgensen MB, Frokjaer VG, Knudsen GM, Ganz M. Generalizability of treatment outcome prediction in major depressive disorder using structural MRI: A NeuroPharm study. Neuroimage Clin. 2022;36:103224
  2. Burmester DR, Madsen MK, Szabo A, Aripaka SS, Stenbæk DS, Frokjaer VG, Elfving B, Mikkelsen JD, Knudsen GM, Fisher PM. Subacute effects of a single dose of psilocybin on biomarkers of inflammation in healthy humans: An open-label preliminary investigation. Compr Psychoneuroendocrinol. 2022 Dec 6;13:100163
  3. Dam VH, Stenbæk DS, Köhler-Forsberg K, Cheng Ip, Ozenne B, Sahakian BJ, Knudsen GM, Jørgensen MB, Frokjaer VG. Evaluating cognitive disturbances as treatment target and predictor of antidepressant action in major depressive disorder: A NeuroPharm study. Transl Psychiatry. 2022 Nov 8;12(1):468
  4. Fisher PM, Ozenne B, Ganz M, Frokjaer VG, Dam VN, Penninx BW, Sankar A, Miskowiak K, Jensen PS, Knudsen GM, Jorgensen MB. Emotional faces processing in major depressive disorder and prediction of antidepressant treatment response: A NeuroPharm study. J Psychopharmacol. 2022 May;36(5):626-636
  5. Köhler-Forsberg K, Ozenne B, Larsen SV, Poulsen AS, Landman EB, Dam VH, Ip CT, Jørgensen A, Svarer C, Knudsen GM, Frokjaer VG, Jørgensen MB. Concurrent anxiety in patients with major depression and cerebral serotonin 4 receptor binding. A NeuroPharm-1 study. Transl Psychiatry. 2022 Jul 11;12(1):273
  6. Larsen SV, Ozenne B, Köhler-Forsberg K, Poulsen AS, Dam VH, Svarer C, Knudsen GM, Jørgensen MB, Frokjaer VG. The Impact of Hormonal Contraceptive Use on Serotonergic Neurotransmission and Antidepressant Treatment Response: Results From the NeuroPharm 1 Study. Front Endocrinol (Lausanne). 2022 Mar 11;13:799675
  7. Macoveanu J, Damgaard V, Ott CV, Knudsen GM, Kessing LV, Miskowiak KW. Action-based cognitive remediation in bipolar disorder improved verbal memory but had no effect on the neural response during episodic memory encoding. Psychiatry Res Neuroimaging. 2022 Jan;319:111418
  8. McCulloch DE, Madsen MK, Stenbæk DS, Kristiansen S, Ozenne B, Jensen PS, Knudsen GM, Fisher PM. Lasting effects of a single psilocybin dose on resting-state functional connectivity in healthy individuals. J Psychopharmacol. 2022 Jan;36(1):74-8410
  9. McCulloch DE, Grzywacz MZ, Madsen MK, Jensen PS, Ozenne B, Armand S, Knudsen GM, Fisher PM, Stenbæk DS. Psilocybin-Induced Mystical-Type Experiences are Related to Persisting Positive Effects: A Quantitative and Qualitative Report. Front Pharmacol. 2022 Mar 9;13:841648
  10. McCulloch DE, Knudsen GM, Barrett FS, Doss MK, Carhart-Harris RL, Rosas FE, Deco G, Kringelbach ML, Preller KH, Ramaekers JG, Mason NL, Müller F, Fisher PM. Psychedelic Resting-state Neuroimaging: A Review and Perspective on Balancing Replication and Novel Analyses. Neurosci Biobehav Rev. 2022 Jul;138:104689
  11. Olsen AS, Lykkebo-Valløe A, Ozenne B, Madsen MK, Stenbæk DS, Armand S, Mørup M, Ganz M, Knudsen GM, Fisher PM. Psilocybin modulation of time-varying functional connectivity is associated with plasma psilocin and subjective effects. Neuroimage. 2022 Dec 1;264:119716
  12. Ozenne B, Budtz-Jørgensen E, Ebert SE. Controlling the familywise error rate when performing multiple comparisons in a Linear Latent Variable Model. Computational Statistics. 2022 March; 10.1007/s00180-022-01214-7
  13. Søndergaard A, Madsen MK, Ozenne B, Armand S, Knudsen GM, Fisher PM, Stenbæk DS. Lasting increases in trait mindfulness after psilocybin correlate positively with the mystical-type experience in healthy individuals. Front Psychol. 2022 Oct 5;13:948729
  14. Zarp Petersen J, Varo C, Skovsen CF, Ott CV, Kjaerstad HL, Vieta E, Harmer CJ, Knudsen GM, Kessing LV, Macoveanu J, Miskowiak KW. Neuronal underpinnings of cognitive impairment in bipolar disorder: A large data-driven functional magnetic resonance imaging study. Bipolar Disord. 2022 Feb;24(1):69-81

 

2021

PhD-theses:

  1. Cheng-Teng Ip. PhD-afhandling: Towards personalized medicine: Effectiveness of pretreatment EEG biomarker in Major Depressive Disorder. København: Eget forlag 2021:1-80. Forsvaret d. 29.01.2021 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet

Papers:

  1. Brandt IM, Köhler-Forsberg K, Ganz M, Ozenne B, Jorgensen MB, Poulsen A, Knudsen GM, Frokjaer VG, Fisher PM. Reward processing in major depressive disorder and prediction of treatment response - Neuropharm study. Eur Neuropsychopharmacol. 2021 Mar;44:23-33
  2. Dam VH, Stenbæk DS, Köhler-Forsberg K, Ip C, Ozenne B, Sahakian BJ, Knudsen GM, Jørgensen MB, Frokjaer VG. Hot and cold cognitive disturbances in antidepressant-free patients with major depressive disorder: a NeuroPharm study. Psychol Med. 2021 Oct;51(14):2347-2356
  3. Donovan LL, Johansen JV, Ros NF, Jaberi E, Linnet K, Johansen SS, Ozenne B, Issazadeh-Navikas S, Hansen HD, Knudsen GM. Effects of a single dose of psilocybin on behaviour, brain 5-HT2A receptor occupancy and gene expression in the pig. Eur Neuropsychopharmacol. 2021 Jan;42:1-11
  4. Ip CT, Ganz M, Dam VH, Ozenne B, Rüesch A, Köhler-Forsberg K, Jørgensen MB, Frokjaer VG, Søgaard B, Christensen SR, Knudsen GM, Olbrich S. NeuroPharm study: EEG wakefulness regulation as a biomarker in MDD. J Psychiatr Res. 2021 Jun 18;141:57-65
  5. Ip CT, Olbrich S, Ganz M, Ozenne B, Köhler-Forsberg K, Dam VH, Beniczky S, Jørgensen MB, Frokjaer VG, Søgaard B, Christensen SR, Knudsen GM. Pretreatment qEEG biomarkers for predicting pharmacological treatment outcome in major depressive disorder: Independent validation from the NeuroPharm study. Eur Neuropsychopharmacol. 2021 Aug;49:101-112
  6. Jørgensen LM, Henriksen T, Mardosiene S, Keller SH, Stenbæk DS, Hansen HD, Jespersen B, Thomsen C, Weikop P, Svarer C, Knudsen GM. Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study. J Cereb Blood Flow Metab. 2021 Aug;41(8):1954-1963
  7. Madsen MK, Stenbæk DS, Arvidsson A, Armand S, Marstrand-Joergensen MR, Johansen SS, Linnet K, Ozenne B, Knudsen GM, Fisher PM. Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience. Eur Neuropsychopharmacol. 2021 Sep;50:121-132
  8. Madsen MK, Knudsen GM. Plasma psilocin critically determines behavioral and neurobiological effects of psilocybin. Neuropsychopharmacology. 2021 Jan;46(1):257-258
  9. Marstrand-Joergensen MR, Madsen MK, Stenbæk DS, Ozenne B, Jensen PS, Frokjaer VG, Knudsen GM, Fisher PM. Default mode network functional connectivity negatively associated with trait openness to experience. Soc Cogn Affect Neurosci. 2021 Sep 7;16(9):950-961
  10. Ozenne B, Budtz-Jørgensen E, Péron J. The asymptotic distribution of the Net Benefit estimator in presence of right-censoring. Stat Methods Med Res. 2021 Nov;30(11):2399-2412
  11. Petersen JZ, Macoveanu J, Kjærstad HL, Knudsen GM, Kessing LV, Miskowiak KW. Assessment of the neuronal underpinnings of cognitive impairment in bipolar disorder with a picture encoding paradigm and methodological lessons learnt. J Psychopharmacol. 2021 Aug;35(8):983-991
  12. Stenbæk DS, Madsen MK, Ozenne B, Kristiansen S, Burmester D, Erritzoe D, Knudsen GM, Fisher PM. Brain serotonin 2A receptor binding predicts subjective temporal and mystical effects of psilocybin in healthy humans. J Psychopharmacol. 2021 Apr;35(4):459-468

 

2020

PhD-theses:

  1. Köhler-Forsberg K. The serotonin 4 receptor binding as a novel imaging marker in major depressive disorder and the association to antidepressant treatment response. København: Eget forlag 2020:1-60. Forsvaret d. 26.06.2020 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet
  2. Lene Lundgaard Donovan. Epigenetic and pharmacological investigations of the pig brain - In vivo and in vitro studies of [11C]Martinostat and psilocybin. København: Eget forlag 2020:1-64. Forsvaret d. 11.09.2020 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet
  3. Martin Korsbak Madsen. Neurobiological effects of 5-HT2AR modulation. København: Eget forlag 2020:1-65. Forsvaret d. 09.10.2020 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet
  4. Vibeke Dam. Shining a light on the black cloud of depression – A study of cognitive markers in Major Depressive Disorder. København: Eget forlag 2020: 1-63. Forsvaret d. 23.10.2020 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet

Papers:

  1. Donovan LL, Magnussen JH, Dyssegaard A, Lehel S, Hooker JM, Knudsen GM, Hansen HD. Imaging HDACs In Vivo: Cross-Validation of the [11C]Martinostat Radioligand in the Pig Brain. Mol Imaging Biol. 2020 Jun;22(3):569-577
  2. Erritzoe D, Ashok AH, Searle GE, Colasanti A, Turton S, Lewis Y, Huiban M, Moz S, Passchier J, Saleem A, Beaver J, Lingford-Hughes A, Nutt DJ, Howes OD, Gunn RN, Knudsen GM, Rabiner EA. Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge. Neuropsychopharmacology. 2020 Apr;45(5):804-810
  3. Hansen HD, Lindberg U, Ozenne B, Fisher PM, Johansen A, Svarer C, Keller SH, Hansen AE, Knudsen GM. Visual stimuli induce serotonin release in occipital cortex: A simultaneous positron emission tomography/magnetic resonance imaging study. Hum Brain Mapp. 2020 Aug 19;41(16):4753-4763
  4. Hjordt LV, Ozenne B, Armand S, Dam VH, Jensen CG, Köhler-Forsberg K, Knudsen GM, Stenbæk DS. Psychometric Properties of the Verbal Affective Memory Test-26 and Evaluation of Affective Biases in Major Depressive Disorder. Front Psychol. 2020 Jun 5;11:961
  5. Holst KK, Budtz-Jørgensen E. A two-stage estimation procedure for non-linear structural equation models. Biostatistics. 2020 Oct 1;21(4):676-691
  6. Köhler-Forsberg K, Jorgensen A, Dam VH, Stenbæk DS, Fisher PM, Ip CT, Ganz M, Poulsen HE, Giraldi A, Ozenne B, Jørgensen MB, Knudsen GM, Frokjaer VG. Predicting Treatment Outcome in Major Depressive Disorder Using Serotonin 4 Receptor PET Brain Imaging, Functional MRI, Cognitive-, EEG-Based, and Peripheral Biomarkers: A NeuroPharm Open Label Clinical Trial Protocol. Front Psychiatry. 2020 Jul 23;11:641
  7. Madsen MK, Fisher PM, Stenbæk DS, Kristiansen S, Burmester D, Lehel S, Páleníček T, Kuchař M, Svarer C, Ozenne B, Knudsen GM. A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding. Eur Neuropsychopharmacol. 2020 Apr;33:71-80
  8. Ozenne B, Fisher PM, Budtz-J⊘rgensen E. Small sample corrections for Wald tests in latent variable models. Journal of the Royal Statistical Society. Series C: Applied Statistics. 2020;69(4):841-861
  9. Ozenne BMH, Scheike TH, Staerk L, Gerds TA. On the estimation of average treatment effects with right-censored time to event outcome and competing risks. Biom J. 2020 May;62(3):751-763
  10. Sander CY, Hansen HD, Wey HY. Advances in simultaneous PET/MR for imaging neuroreceptor function. J Cereb Blood Flow Metab. 2020 Jun;40(6):1148-1166

 

2019

PhD-theses:

  1. Deen M. PET investigations of brain serotonin receptor binding in migraine patients. København: Eget forlag 2018:1-54. Forsvaret d. 04.01.2019 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet

Papers:

  1. Deen M, Hougaard A, Hansen HD, Svarer C, Eiberg H, Lehel S, Knudsen GM, Ashina M. Migraine is associated with high brain 5-HT levels as indexed by 5-HT4 receptor binding. Cephalalgia. 2019 Apr;39(4):526-532
  2. Deen M, Hougaard A, Hansen HD, Schain M, Dyssegaard A, Knudsen GM, Ashina M. Association Between Sumatriptan Treatment During a Migraine Attack and Central 5-HT1B Receptor Binding. JAMA Neurol. 2019 Jul 1;76(7):834-840
  3. Madsen MK, Fisher PM, Burmester D, Dyssegaard A, Stenbæk DS, Kristiansen S, Johansen SS, Lehel S, Linnet K, Svarer C, Erritzoe D, Ozenne B, Knudsen GM. Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels. Neuropsychopharmacology. 2019 Jun;44(7):1328-1334
  4. Ott CV, Vinberg M, Bowie CR, Christensen EM, Knudsen GM, Kessing LV, Miskowiak KW. Correction to: Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial. Trials. 2019 Apr 8;20(1):20

Book chapters:

  1. Landolt HP, Holst SC, Valomon A. Clinical and Experimental Human Sleep-Wake Pharmacogenetics. Handb Exp Pharmacol. 2019;253:207-241. doi: 10.1007/164_2018_175.

 

2018

PhD-theses:

  1. Beliveau V. Functional and Molecular Imaging of the Serotonin System in the Human Brain. København: Eget forlag 2018:1-54. Forsvaret d. 27.02.2018 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet
  2. Jørgensen LM. Pharmacological and DBS-induced changes in cerebral serotonin release. København: Eget forlag 2018:1-82. Forsvaret d. 09.03.2018 ved Københavns Universitet, Det Sundhedsvidenskabelige Fakultet.

Papers:

  1. Deen M, Hansen HD, Hougaard A, Nørgaard M, Eiberg H, Lehel S, Ashina M, Knudsen GM. High brain serotonin levels in migraine between attacks: A 5-HT4 receptor binding PET study. Neuroimage Clin. 2018 Jan 28;18:97-102
  2. Deen M, Hansen HD, Hougaard A, da Cunha-Bang S, Nørgaard M, Svarer C, Keller SH, Thomsen C, Ashina M, Knudsen GM. Low 5-HT1B receptor binding in the migraine brain: A PET study. Cephalalgia. 2018 Mar;38(3):519-527
  3. Ott CV, Vinberg M, Bowie CR, Christensen EM, Knudsen GM, Kessing LV, Miskowiak KW. Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial. Trials. 2018 Sep 12;19(1):487

 

2017

  1. Deen M, Christensen CE, Hougaard A, Hansen HD, Knudsen GM, Ashina M. Serotonergic mechanisms in the migraine brain - a systematic review. Cephalalgia. 2017 Mar;37(3):251-264
  2. Hansen HD, Mandeville JB, Sander CY, Hooker JM, Catana C, Rosen BR, Knudsen GM. Functional characterization of 5-HT1B receptor drugs in nonhuman primates using simultaneous PET-MR. J Neurosci. 2017 Nov 1;37(44):10671-10678
  3. Stenbæk DS, Dam VH, Fisher PM, Hansen N, Hjordt LV, Frøkjær VG. No evidence for a role of the serotonin 4 receptor in five-factor personality traits: A positron emission tomography brain study. PLoS One. 2017 Sep 7;12(9):e0184403

 

2016

  1. Mandeville JB, Sander CY, Wey HY, Hooker JM, Hansen HD, Svarer C, Knudsen GM, Rosen BR. A regularized full reference tissue model for PET neuroreceptor mapping. Neuroimage. 2016 Jun 27;139:405-414